Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β
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چکیده
منابع مشابه
TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4 includes activins and bone morphogenetic proteins
includes activins and bone morphogenetic proteins Atsuhito Nakao1, Takeshi Imamura2, (BMPs). TGF-β superfamily members induce a multitude Serhiy Souchelnytskyi, of effects and have been shown to control proliferation, Masahiro Kawabata2, Akira Ishisaki, differentiation, migration and apoptosis of many different Eiichi Oeda2, Kiyoshi Tamaki, cell types (Roberts and Sporn, 1993). They act via lig...
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Background: During its latent infection, HSV-1 produces only a miRNA precursor called LAT, which encodes six distinct miRNAs. Recent studies have suggested that some of these miRNAs could target cellular mRNAs. One of the key cell signaling pathways that can be affected by HSV-1 is the TGF-β/Smad pathway. Herein, we investigated the potential role of the LAT as well as three LAT-derived miRNAs ...
متن کاملSmad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis.
The transforming growth factor beta (TGF-β) pathway plays key roles in development and cancer. TGF-β signaling converges on the Smad2 and Smad3 effectors, which can either cooperate or antagonize to regulate their transcriptional targets. Here we performed in vivo and in silico experiments to study how such cooperativity and antagonism might function during neurogenesis. In vivo electroporation...
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Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic mutations in the pathway members TGFBR2 and SMAD4, but to what extent mutations in SMAD2 or SMAD3 contribute to tumorigenesis is unclear. A cohort of 744 primary CRCs and 36 CRC cell lines were sequenced for SMAD4, SMAD2,...
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1) Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892 2) Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461 3) Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461 4) Cancer and Developmental Biology Laboratory, Frederick Cancer Research and Development Center, National Cancer Institute...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2000
ISSN: 0261-4189,1460-2075
DOI: 10.1093/emboj/19.19.5178